1. I saw Dr. Bieber today. He's the kidney doctor from Kootenai Health I've been seeing since January, 2020.
We talked at some length today about the early signs of my immune system rejecting my new kidney, how things look now, and what the plan is moving forward.
I'm going to write at some length recounting, as best I can, our conversation.
First of all, a vitally important aspect of transplantation is to keep the recipient's immune system from rejecting the new kidney. My immune system recognizes that the transplanted organ is not one I had at birth and its response is to attack it and shut it down -- that is, reject it.
So, early on, when I received this new kidney, part of the process was to front load my system with a high volume of anti-rejection medicine(s) and to begin my lifelong regimen of taking anti-rejection meds daily.
As a result, my body's immunity against infection of any kind was greatly diminished.
From that point forward, and for as long as I am alive, the transplant team at Sacred Heart in Spokane and Dr. Bieber at Kootenai Health, will always be working to strike a balance between keeping enough anti-rejection meds in my system so that my immune system doesn't attack/reject my new kidney, but, at the same time, keeping my immune system strong enough to ward off infection.
So here's what Dr. Bieber thinks happened in the last few months. It's not uncommon and this problem can be addressed and treated and that's what is happening with me right now.
Two viruses are of concern post-transplant: one is known as the BK virus and the other is the CMV.
My labs a while back revealed a low level presence of these two viruses in my system and so the transplant team lowered my anti-rejection dosage, thus increasing the strength of my immune system, so it could go after these viruses.
That worked.
But, my strengthened immune system also detected the unnatural organ in my body and began to do its job of going after my new kidney.
The doctors caught this rejection activity early on.
This activity is what they and I refer to as early signs of rejection.
I had a biopsy performed. It confirmed that my immune system created some inflammation in my kidney.
To tamp down that inflammation -- one way to put it would be to say to call off the dogs of immunity -- I went to the Kootenai Infusion Center two days in a row for a couple heavy doses of steroids and then for about five days, ingested an increased dosage of Prednisone that began at a high level and then tapered off until I was back to my regular dosage again.
If I understood Dr. Bieber correctly today, the way my body is signaling that rejection is or has been under way is through my labs showing an increase of protein in my urine.
It's atypical. Typically, the body signals this in other additional ways.
Dr. Bieber hasn't seen a case like this since he was in medical school, but, as he put it, "I'm not a transplant nephrologist" and he is confident that the specialists in Spokane are more familiar with how my body is presenting these early signs of rejection.
As with so many things in the world of medical treatment, the key to successfully intervening against this rejection is early detection.
That's happened.
The next course of action is regular monitoring.
And weekly labs.
And working with the doctors to strike the right balance between an effective amount of daily anti-rejection meds while working to keep my immune system as strong as possible but not so strong that it's trying to reject my kidney, but strong enough to fend off other viruses (like BK and CMV) and other infections.
So you might be wondering, while my new kidney has been hassled by my immune system, how is it functioning.
The answer: really well.
My renal panel results have been stable and positive.
The docs aren't alarmed.
They monitor how things are going.
When needed, they adjust dosages.
I hope in this blog post I got this all pretty close to being right.
If not, I'll write corrections in the future.
2. Debbie wanted me to mail out a couple of items and asked me to look for them "somewhere in my piles of junk". I looked here and there and everywhere, upstairs, main floor, basement, and before I went to the doctor this morning, I found the items!
I got them ready to mail and went to the Post Office and was very happy to get this little errand completed.
3. Kidney talk tires me out a bit.
I had saved myself a few slices of pizza from Tuesday night to relax me when I got home.
They worked.
I also hadn't worked Thursday's NYTimes crossword puzzle yet, so I relaxed with it.
At 7:00, the Friday puzzle came on line and I worked it.
The pizza and puzzles provided a welcome break from having my mind on medical matters, matters I'm maintaining my optimism about and am hoping my visit to Spokane on Thursday will bolster my optimism.